Document 0527
 DOCN  M9480527
 TI    Human immunodeficiency virus type 1 seroconversion in women with genital
       ulcers.
 DT    9410
 AU    Plourde PJ; Pepin J; Agoki E; Ronald AR; Ombette J; Tyndall M; Cheang M;
       Ndinya-Achola JO; D'Costa LJ; Plummer FA; Department of Medical
       Microbiology, University of Nairobi, Kenya.
 SO    J Infect Dis. 1994 Aug;170(2):313-7. Unique Identifier : AIDSLINE
       MED/94308595
 AB    Genital ulcers are implicated as a risk factor enhancing susceptibility
       to human immunodeficiency virus type 1 (HIV-1) infection. A prospective
       study to determine the incidence of and risk factors associated with
       acquisition of HIV-1 in women with genital ulcers was done.
       HIV-1-seronegative women with genital ulcers attending a clinic for
       sexually transmitted diseases in Nairobi were followed to HIV-1
       seroconversion over a 6-month period. Of 81 women, 10 seroconverted to
       HIV-1. The crude 6-month incidence of HIV-1 infection was 12%. Risk
       factors associated with seroconversion included cervical ectopy (rate
       ratio [RR], 4.9; 95% confidence interval [CI], 1.5-15.6) and pelvic
       inflammatory disease (RR, 6.3; 95% CI, 1.9-20.4). Thus, cervical ectopy
       and pelvic inflammatory disease may increase susceptibility to HIV-1 in
       women with genital ulcers.
 DE    Adnexitis/COMPLICATIONS  Adolescence  Adult  Cervix Uteri/ABNORMALITIES
       Confidence Intervals  Female  Follow-Up Studies  Genital Diseases,
       Female/*COMPLICATIONS  Human  HIV Seropositivity/*EPIDEMIOLOGY  *HIV-1
       Incidence  Kenya/EPIDEMIOLOGY  Middle Age  Prospective Studies
       Prostitution  Risk Factors  Sex Behavior  Support, Non-U.S. Gov't
       Ulcer/COMPLICATIONS  JOURNAL ARTICLE

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